Blythewood is a historic mansion in Amite City, Louisiana, U.S..
The land was granted by New Spain to Reliegh Self. A cotton plantation with a mansion was built prior to the American Civil War of 1861–1865. However, the mansion was subsequently burned down.A new mansion was built for Daniel Hardy Sanders from 1885 to 1888. It was designed in the Colonial Revival architectural style by Drake & Anderson. It has been listed on the National Register of Historic Places since June 25, 1982. It serves as a bed & breakfast.