Gmina Wilczyce is a rural gmina (administrative district) in Sandomierz County, Świętokrzyskie Voivodeship, in south-central Poland. Its seat is the village of Wilczyce, which lies approximately 10 kilometres (6 mi) north-west of Sandomierz and 75 km (47 mi) east of the regional capital Kielce.
The gmina covers an area of 69.94 square kilometres (27.0 sq mi), and as of 2006 its total population is 3,928 (3,800 in 2013).
Gmina Wilczyce contains the villages and settlements of Bożęcin, Bugaj, Dacharzów, Daromin, Dobrocice, Gałkowice-Ocin, Łukawa, Ocinek, Pęczyny, Pielaszów, Przezwody, Radoszki, Tułkowice, Wilczyce, Wysiadłów and Zagrody.
Gmina Wilczyce is bordered by the gminas of Dwikozy, Lipnik, Obrazów, Ożarów and Wojciechowice.