Kupyn (Ukrainian: Купин; Russian: Купин Kupin) is a village in the Horodotskyi Raion of Khmelnytskyi Oblast, in Ukraine.
Jews began to settle in Kupin in the 18th century. In 1897 1,351 Jews were living in the town. In 1905, Cossacks carried out a pogrom, during which they looted property and murdered several Jews. On March 6, 1919, during the Russian civil war, the Jews suffered from pogroms. In 1926 37 percent of a total population were Jewish inhabitants. The Germans occupied Kupin in July 1941. In September 1942, Einsatzgruppen of the Ukrainian auxiliary police murdered about 300 Jews in a mass execution on the outskirts of the town near the Jewish cemetery.
The town was liberated by the Red Army in March 1944.