Szerszenie [ʂɛrˈʂɛɲɛ] is a village in the administrative district of Gmina Siemiatycze, within Siemiatycze County, Podlaskie Voivodeship, in north-eastern Poland. It lies approximately 7 kilometres (4 mi) south-east of Siemiatycze and 81 km (50 mi) south of the regional capital Białystok.
According to the 1921 census, the village was inhabited by 123 people, among whom 12 were Roman Catholic, 106 Orthodox, 1 Greek Catholic and 4 Mosaic. At the same time, all inhabitants declared Polish nationality. There were 23 residential buildings in the village.